Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential
نویسندگان
چکیده
منابع مشابه
Medicinal Chemistry and Molecular Pharmacology of GABA Receptors and Glutamate Transporters— Complementary Structure–Activity Relationships
GABA and glutamate are the major inhibitory and excitatory neurotransmitters, respectively, in the human brain. Many GABA and glutamate receptors and transporters are key protein targets for drug development, and many known CNS drugs act on these targets. There have been a substantial number of traditional studies of structure–activity relationships in this area. The advent of modern molecular ...
متن کاملAyahuasca: Pharmacology, neuroscience and therapeutic potential.
Ayahuasca is the Quechua name for a tea obtained from the vine Banisteriopsis caapi, and used for ritual purposes by the indigenous populations of the Amazon. The use of a variation of the tea that combines B. caapi with the leaves of the shrub Psychotria viridis has experienced unprecedented expansion worldwide for its psychotropic properties. This preparation contains the psychedelic 5-HT2A r...
متن کاملPharmacology and potential therapeutic uses of cannabis.
Throughout history, cannabis has been used as a natural therapeutic herb. Indeed the discovery of the remains of a young girl in Jerusalem who died in childbirth sometime around the third century AD, revealed residues of cannabis in the pelvic region. This strongly suggests that cannabis was used in medical practice in early human civilizations. Cannabis was first used as a medicine in Britain ...
متن کاملPharmacology and Molecular Biology of A2a Adenosine Receptors
Okusa, Mark D. A2A adenosine receptor: a novel therapeutic target in renal disease. Am J Physiol Renal Physiol 282: F10–F18, 2002.— Present strategies in the treatment of inflammatory renal injury have focused on developing agents that specifically target individual mechanisms thought to contribute toward the pathogenesis of the disease. Such an approach is hindered by redundancies in the infla...
متن کاملTherapeutic potential of adenosine analogues and conjugates.
This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), belonging to the family of G-protein-coupled receptors and widely distributed throughout the body. Moreover, adenosine is involved in key biochemical ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 1992
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm00081a001